Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5(3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica
نویسندگان
چکیده
منابع مشابه
Sea ranching of the marine sponge Negombata magnifica (Demospongiae, Latrunculiidae) as a first step for latrunculin B mass production
Marine sponges are a rich source of bioactive metabolites that can potentially be used as lead compounds to treat various human diseases. Due to the difficulty in obtaining a steady supply of such metabolites, few of these compounds have reached the clinical trials stage. Sponge sea ranching is one of the most promising methods to overcome this bsupply problemQ. The Red Sea sponge Negombata mag...
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Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A [8] was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesize...
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ژورنال
عنوان ژورنال: Marine Drugs
سال: 2021
ISSN: 1660-3397
DOI: 10.3390/md19040214